The latest research published in the American Journal of Osteopathic medicine shows that when magnesium levels are low, vitamin D cannot be metabolized properly and can actually be detrimental to your health by increasing calcium and phosphate which can result in vascular calcification or kidney stones.
This research matches up to what we currently know about vitamin D including how it relates to LDL cholesterol, sulfur foods, cholesterol sulfate as well as the difference between sulfated vitamin D and unsulfated vitamin D.
Vitamin D affects the genes, the innate immune system and the VDR (vitamin D nuclear receptor)
This vitamin has been researched extensively, yet many mysteries remain. This latest research shows that if a person has magnesium deficiencies, if you take vitamin D supplementation it could be detrimental. This supports previous thoughts that vitamin D metabolism requires vitamin C, vitamin K2, calcium and magnesium.
It should also be noted that many people who are magnesium deficient often suffer from Adrenal Insufficiency, for adrenaline keeps magnesium in suspension.
Role of Magnesium in Vitamin D Activation and Function