Genetics influence every aspect of human physiology, adaptation and development; obesity is no exception. Obesity is rarely caused only by genetics, it is also influenced by lifestyle factors. Genetics do not control your life or predict your destiny.
Genetic Factors That Influence Obesity:
- FTO gene – A very common gene strongly linked with obesity. People having this FTO gene varian does make one more susceptible to obesity up to about 70%.
- Ankryn-B – A gene variant that could cause people to put on a lot of weight at no fault of their own. A study showed that this gene variation causes fat cells to bring glucose into the cell much faster than normal. Researchers called this fault-free obesity. This gene is also linked to many other conditions such as diabetes, irregular heartbeat, muscular dystrophy, autism, etc. However, this gene variant is not very common.
- 14-3-3 Zeta – A protein found in every single cell in the body. Researchers found when they silenced this protein there was 50% reduction in the amount of visceral fat(white fat). This protein controls adipogenesis, how the body creates new fat cells, and it also controls the growth of the fat cells. You’re developing more fat cells and its making them larger.
There are 37 genes that are very well established for really affecting obesity. Based on research it appears that when a BMI is higher, this activates obesity causing genes. These obesity causing genes have predisposition to cause other conditions and challenges.
When your body is optimized (meaning optimized mitochondria, cell energy, cellular communications, balance of hormones, and simply giving it the fuel it needs), everything works great; energy is high, ailments are far and few. When you start to gain a little bit of weight, as long as it is caught early, you can get back to that optimized state fairly effortlessly. If weight gain and disruption of hormones, neurotransmitters, receptors, etc. continues for an extended amount of time, you’ll find that the weight loss strategies successfully done in the past will not work as they use to work. Cellular communications, hormones, pathways, etc. are not working optimally and the body is out of balance. This can lead to a snowball effect of health challenges such as becoming leptin resistant, thyroid resistant, insulin resistant, and more.
How Do You Get Back to an Optimized and Balance State:
Learning how to fuel, balance, and optimize your body by understanding which foods, food compounds, supplements, and overall lifestyle factors will be key to your particular health needs and challenges. For example, certain vegetables will help heal Colitis and some will make it worse. Studies show that broccoli is good for healing the inflammatory response in Colitis, but bad for hypothyroid conditions. When you have some information about your health, you can develop a plan to correct issues and get back to optimal health.
Remember, your environment affects your genes, your foods affect your genes, your foods affects your hormones, your foods affect neurotransmitters. You can overcome health challenges that are linked to genes. You may have a higher predisposition that’s all, nothing more than that.